AZD2423
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
Product Specifications
CAS Number
[1229603-37-5]
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azd2423.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C([C@@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3
Molecular Formula
C20H29ClFN5O2
Molecular Weight
425.93
References & Citations
[1]AZD2423.|[2]John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423.|[3]Kalliomäki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154 (5) :761-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR2
Available Sizes
Curated Selection
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