AZD2423
Product Specifications
UNSPSC Description
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
Target Antigen
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azd2423.html
Smiles
O=C(N1CCN(C([C@@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3
Molecular Weight
425.93
References & Citations
[1]AZD2423.|[2]John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423.|[3]Kalliomäki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135891/AZD2423-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135891/AZD2423-SDS-MedChemExpress.pdf
CAS Number
1229603-37-5
Available Sizes
Curated Selection
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