PYCR1-IN-1

PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects[1].

Product Specifications

CAS Number

[709-85-3]

UNSPSC

12352005

Hazard Statement

H302, H314, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pycr1-in-1.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CCN(C)CC1=CC=C(Br)C=C1

Molecular Formula

C11H12BrN

Molecular Weight

238.13

Precautions

H302, H314, H335

References & Citations

[1]Kirsty Milne, et al. A fragment-like approach to PYCR1 inhibition. Bioorg Med Chem Lett. 2019 Sep 15;29 (18) :2626-2631.|[2]Forlani G, et al., Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells. J Enzyme Inhib Med Chem. 2021 Dec;36 (1) :1248-1257.