PARP-1 rabbit pAb

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],

Product Specifications

Background

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

UniProt

P09874

Swiss Prot

P09874

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human PARP-1

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; WB

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, WB 1:500-2000

Molecular Weight

113kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

113kD

Fragment

IgG

Subcellular Location

Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .

Other Product Names

Poly [ADP-ribose] polymerase 1 (PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD (+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1)