Cinchonine (monohydrochloride hydrate)

Cinchonine ((8R,9S) -Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis[1].

Product Specifications

CAS Number

[206986-88-1]

Product Name Alternative

(8R,9S) -Cinchonine (monohydrochloride hydrate) ; LA40221 (monohydrochloride hydrate)

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Apoptosis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cinchonine-monohydrochloride-hydrate.html

Solubility

10 mM in DMSO

Smiles

O[C@@H](C1=CC=NC2=CC=CC=C12)[C@]3([H])[N@@]4C[C@H](C=C)[C@@H](CC4)C3.[H]Cl.[x].O

Molecular Formula

C19H22N2O.HCl.xH2O

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Jin ZL, et, al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.