SIRT2-IN-11

SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].

Product Specifications

CAS Number

[1005095-06-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt2-in-11.html

Purity

99.94

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2NC(C3C(C4CCC3C4)C2=C1)C5=CC=CC=C5)N

Molecular Formula

C21H22N2O

Molecular Weight

318.41

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hoffmann G, et al. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289 (8) :5208-16.