PF-AKT400

PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM) .

Product Specifications

CAS Number

[1004990-28-6]

Product Name Alternative

AKT protein kinase inhibitor

UNSPSC

12352005

Target

Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AKT-inhibitor.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N[C@@](CC1)(CNC(C2=CC=C(F)C=C2F)=O)CN1C3=C4C(NC=C4CC)=NC=N3

Molecular Formula

C20H22F2N6O

Molecular Weight

400.43

References & Citations

[1]Chen SF, et al. Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19 (11) :5097-5112.|[2]Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53 (12) :4615-4622.