OX40/TNFRSF4, Mouse (HEK293, His)

OX40 (TNFRSF4), is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells. OX40 can be activated by OX40 Ligand, thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs[1][2]. OX40/TNFRSF4 Protein, Mouse (HEK293, His) is a recombinant mouse OX40 (V20-P211) with C-terminal 6*His tag, which is produced in HEK293.

VTARRLNCVK HTYPSGHKCC RECQPGHGMV SRCDHTRDTL CHPCETGFYN EAVNYDTCKQ CTQCNHRSGS ELKQNCTPTQ DTVCRCRPGT QPRQDSGYKL GVDCVPCPPG HFSPGNNQAC KPWTNCTLSG KQTRHPASDS LDAVCEDRSL LATLLWETQR PTFRPTTVQS TTVWPRTSEL PSPPTLVTPE GP

[1]Kaur D, et al. OX40/OX40 ligand interactions in T-cell regulation and asthma. Chest. 2012 Feb;141(2):494-499.|[2]Fu N, et al. The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases. Front Immunol. 2021 Jun 21;12:670637.|[3]Buglio D, et al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood. 2011 Mar 10;117(10):2910-7.|[4]Arestides RS, et al. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur J Immunol. 2002 Oct;32(10):2874-80. |[5]Kotani A, et al. Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5. Immunol Lett. 2002 Oct 21;84(1):1-7. |[6]Wu LY, et al. Recombinant OX40 attenuates neuronal apoptosis through OX40-OX40L/PI3K/AKT signaling pathway following subarachnoid hemorrhage in rats. Exp Neurol. 2020 Apr;326:113179.