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H2-Gamendazole

H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research[1].

Product Specifications

CAS Number

877768-84-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

CFTR; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/h2-gamendazole.html

Purity

98.20

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CCC1=NN(CC2=CC=C(C=C2Cl)Cl)C3=C1C=CC(C(F)(F)F)=C3)O

Molecular Formula

C18H13Cl2F3N2O2

Molecular Weight

417.21

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Shirin V Sundar, et al. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323 (4) :F492-F506.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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