Raphin1 (acetate)
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B) . Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Product Specifications
CAS Number
[2242616-04-0]
UNSPSC
12352005
Hazard Statement
H301
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/raphin1-acetate.html
Purity
99.93
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N.CC(O)=O
Molecular Formula
C10H12Cl2N4O2
Molecular Weight
291.13
Precautions
H301
References & Citations
[1]Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174 (5) :1216-1228.e19.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2024 Feb 5.|Nature. 2023 Sep;621 (7977) :188-195.|Nat Commun. 2024 Aug 9;15 (1) :6810.
Available Sizes
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