LHQ490
LHQ490 is a selective FGFR2 inhibitor, with an IC50 of 5.2 nM. LHQ490 efficiently inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 1.4 nM. LHQ490 inhibits FGFR2-driven cancer cell proliferation and induces apoptosis of FGFR2-driven cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lhq490.html
Smiles
C=CC(NC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3N2C)N)C4=CC=C(C(F)=C4)C5(COC5)N(C(C)C)CC)=O
Molecular Formula
C30H33FN6O2
Molecular Weight
528.62
References & Citations
[1]Li H, et al. Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor. Eur J Med Chem. 2024 Jun 5;272:116473.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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