Lurbinectedin-d3
Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
Product Specifications
Product Name Alternative
PM01183-d3; LY-01017-d3
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.25
Solubility
DMSO : 3.57 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H]([C@@](CC1=CC(C)=C2OC)([H])N(C)[C@]3([H])C1=C2O)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]3([H])[C@@](SC[C@@]4(NCC8)C9=C8C%10=CC(OC([2H])([2H])[2H])=CC=C%10N9)([H])C5=C7OC(C)=O
Molecular Formula
C41H41D3N4O10S
Molecular Weight
787.89
References & Citations
[1]Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11 (3) :e0151050.|[2]Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161 (5) :1099-110.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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