L755507

L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L755507 enhances the homology-directed repair (HDR) -mediated genome editing[1][2][3].

Product Specifications

CAS Number

[159182-43-1]

UNSPSC

12352005

Target

Adrenergic Receptor; CRISPR/Cas9

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/L755507.html

Purity

98.89

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O

Molecular Formula

C30H40N4O6S

Molecular Weight

584.73

References & Citations

[1]Sato M, et al. The beta3-adrenoceptor agonist 4-[[ (Hexylamino) carbonyl]amino]-N-[4-[2-[[ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S) -N-[4-[2-[[3-[3- (acetamidomethyl) phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74 (5) :1417-28.|[2]Guoling Li, et al. Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells. Sci Rep. 2017; 7: 8943.|[3]Murakami Y, et al. An effective double gene knock-in strategy using small-molecule L755507 in the medaka fish (Oryzias latipes) . Genesis. 2022;60 (1-2) :e23465.