NAT

NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases[1].

Product Specifications

CAS Number

[831243-31-3]

UNSPSC

12352005

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nat.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)(C1=C(C=CC=C1)OCC(NC2=CC=C(C=C2)O)=O)C

Molecular Formula

C18H21NO3

Molecular Weight

299.36

References & Citations

[1]Wang L, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy [published online ahead of print, 2022 Mar 16]. Eur J Med Chem. 2022;236:114260.