EGFR ligand-9
EGFR ligand-9 is an EGFR ligand. EGFR ligand-9 can be used for synthesis of PROTAC EGFR degrader 9 (HY-161536) [1].
Product Specifications
CAS Number
[2992670-44-5]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-ligand-9.html
Purity
98.80
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(C(C1=CN(C2=CC=CC=C21)S(=O)(CC)=O)=N3)=CN=C3NC4=CC=C(C=C4)N5CCNCC5
Molecular Formula
C25H25F3N6O2S
Molecular Weight
530.57
References & Citations
[1]Zhang H, et al. Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation. ACS Med Chem Lett. 2022 Jan 14;13 (2) :278-283.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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