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EGFR ligand-9

EGFR ligand-9 is an EGFR ligand. EGFR ligand-9 can be used for synthesis of PROTAC EGFR degrader 9 (HY-161536) [1].

Product Specifications

CAS Number

[2992670-44-5]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-ligand-9.html

Purity

98.80

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC(F)(F)C(C(C1=CN(C2=CC=CC=C21)S(=O)(CC)=O)=N3)=CN=C3NC4=CC=C(C=C4)N5CCNCC5

Molecular Formula

C25H25F3N6O2S

Molecular Weight

530.57

References & Citations

[1]Zhang H, et al. Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation. ACS Med Chem Lett. 2022 Jan 14;13 (2) :278-283.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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