Boc-piperazine-benzoic acid
Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229) [1].
Product Specifications
CAS Number
[162046-66-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-piperazine-benzoic-acid.html
Purity
99.37
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(N2CCN(C(OC(C)(C)C)=O)CC2)C=C1
Molecular Formula
C16H22N2O4
Molecular Weight
306.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64 (17) :12831-12854.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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