EZM 2302

EZM 2302 is a potent and orally active CARM1 inhibitor with an IC50 value of 6 nM. EZM 2302 shows antiproliferative activity and anti-tumor activity. EZM 2302 inhibits PABP1 and SMB expression[1].

Product Specifications

CAS Number

[1628830-21-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EZM_2302.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CNC[C@@H](O)COC1=CC=C(Cl)C(C2=NC(N3CC4(CCN(C(OC)=O)CC4)C3)=C(C)C(C5=C(C)ON=C5C)=N2)=C1

Molecular Formula

C29H37ClN6O5

Molecular Weight

585.09

Precautions

H302

References & Citations

[1]Drew AE, et al. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 Dec 21;7 (1) :17993.