Alpha-Naphthoflavone

Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatasearomatase. IC 50 and K I value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].

Product Specifications

CAS Number

[604-59-1]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Apoptosis; Aryl Hydrocarbon Receptor; Cytochrome P450

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alpha-naphthoflavone.html

Purity

99.76

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43

Molecular Formula

C19H12O2

Molecular Weight

272.30

Precautions

H302, H413

References & Citations

[1]Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46 (3) :381-8.|[2]Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368 (5) :377-85.|[3]Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105.|[4]Xia H, et al. Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. Biomed Pharmacother. 2019 Oct;118:109287.