Glucosamine (hydrochloride) (Standard)

Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride) . This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

Product Specifications

CAS Number

[66-84-2]

Product Name Alternative

D- (+) -Glucosamine hydrochloride (Standard) ; Chitosamine hydrochloride (Standard)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/glucosamine-hydrochloride-standard.html

Purity

99.96

Smiles

O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.Cl

Molecular Formula

C6H14ClNO5

Molecular Weight

215.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38 (1) :212-9.|[2]Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44 (5) :1699-706.|[3]Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl) . 2013 Nov;91 (11) :1273-84.|[4]Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45 (4 Suppl) :S12-7.