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Bis-propargyl-PEG3

Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

126422-58-0

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bis-propargyl-peg3.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CCOCCOCCOCCOCC#C

Molecular Formula

C12H18O4

Molecular Weight

226.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.|[2]Rice DR, et al. Antiplasmodial activity of targeted zinc (II) -dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25 (10) :2754-2760.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Frequently Asked Questions

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