Crisaborole

Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.

Product Specifications

CAS Number

[906673-24-3]

Product Name Alternative

AN-2728; PF-06930164

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/AN-2728.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1

Molecular Formula

C14H10BNO3

Molecular Weight

251.05

Precautions

H302, H315, H319, H335

References & Citations

[1]Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2129-32.|[2]Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10 (11) :1236-42.