KS106

KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1].

Product Specifications

CAS Number

[2408477-50-7]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH) ; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ks106.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(C(F)(F)F)=CC=C32)=O)=O)N.Br

Molecular Formula

C18H15BrF3N3O2S

Molecular Weight

474.29

References & Citations

[1]Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962.