Benfotiamine

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19[1][2][3].

Product Specifications

CAS Number

[22457-89-2]

Product Name Alternative

S-Benzoylthiamine O-monophosphate

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

HIV; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/benfotiamine.html

Purity

99.38

Solubility

DMSO : ≥ 50 mg/mL|H2O : 0.67 mg/mL (ultrasonic)

Smiles

CC1=NC=C(CN(/C(C)=C(CCOP(O)(O)=O)/SC(C2=CC=CC=C2)=O)C=O)C(N)=N1

Molecular Formula

C19H23N4O6PS

Molecular Weight

466.45

Precautions

H302, H312, H332

References & Citations

[1]Allowitz KV, et, al. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19. Future Med Chem. 2022 Jun;14 (11) :809-826.|[2]Bozic I, et, al. Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS One. 2015 Feb 19;10 (2) :e0118372.|[3]Wu S, et, al. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. Neurosci Lett. 2006 Feb 13;394 (2) :158-62.