4-Octylphenol

4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg) /Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR) ) /IκBα/NF-κB pathway[1][2].

Product Specifications

CAS Number

[1806-26-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Complement System; NF-κB; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-octylphenol.html

Purity

98.0

Smiles

CCCCCCCCC1=CC=C(C=C1)O

Molecular Formula

C14H22O

Molecular Weight

206.32

Precautions

H315, H319

References & Citations

[1]E Bendsen, et al. Effect of 4-octylphenol on germ cell number in cultured human fetal gonads. 2001 Feb;16 (2) :236-43.|[2]Qi Sun, et al. Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7/IκBα/NF-κB pathway in common carp (Cyprinus carpio) gills. Aquat Toxicol. 2022 Aug:249:106211.