Y-27632 (dihydrochloride)
Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I Ki=220 nM; ROCK-II Ki=300 nM) . Y-27632 dihydrochloride shows antiepileptic effects[1][2][3][4].
Product Specifications
CAS Number
[129830-38-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Organoid; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Y-27632-dihydrochloride.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl
Molecular Formula
C14H23Cl2N3O
Molecular Weight
320.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ROCK1; ROCK2
Citation 01
Available Sizes
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