A-582941 (dihydrochloride)

A-582941 dihydrochloride is a potent, selective and brain-penetrant partial agonist of α7 nAChR, with Kis of 10.8 and 16.7 nM in rat brain membranes and human frontal cortex, respectively. A-582941 dihydrochloride also binds to human 5-HT3 receptor with a Ki of 150 nM. A-582941 has the potential for cognitive deficits associated with various neurodegenerative and psychiatric disorders research[1][2].

Product Specifications

CAS Number

[848591-90-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

5-HT Receptor; nAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-582941-dihydrochloride.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CC(CN(C2=NN=C(C3=CC=CC=C3)C=C2)C4)C4C1.[H]Cl.[H]Cl

Molecular Formula

C17H22Cl2N4

Molecular Weight

353.29

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Anderson DJ, et, al. [3H]A-585539 [ (1S,4S) -2,2-dimethyl-5- (6-phenylpyridazin-3-yl) -5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J Pharmacol Exp Ther. 2008 Jan; 324 (1) : 179-87.|[2]Tietje KR, et, al. Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci Ther. Spring 2008; 14 (1) : 65-82.