PARP10/15-IN-1
Product Specifications
UNSPSC Description
PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1].
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp10-15-in-1.html
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1NNC(C2=C1C=CC(OCC3=CSC=C3)=C2)=O
Molecular Weight
274.30
References & Citations
[1]Nizi MG, et, al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Apr 19;237:114362.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143398/PARP10-15-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143398/PARP10-15-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2892065-01-7
Available Sizes
Curated Selection
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