PARP10/15-IN-1

PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1].

Product Specifications

CAS Number

[2892065-01-7]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp10-15-in-1.html

Concentration

10mM

Purity

95.04

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NNC(C2=C1C=CC(OCC3=CSC=C3)=C2)=O

Molecular Formula

C13H10N2O3S

Molecular Weight

274.30

References & Citations

[1]Nizi MG, et, al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Apr 19;237:114362.