Edasalonexent

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

Product Specifications

CAS Number

[1204317-86-1]

Product Name Alternative

CAT-1004

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Edasalonexent.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCCNC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)C1=CC=CC=C1O

Molecular Formula

C31H42N2O3

Molecular Weight

490.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Hammers DW, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016 Dec 22;1 (21) :e90341.|[2]Donovan JM, et al. A Novel NF-κB Inhibitor, Edasalonexent (CAT-1004), in Development as a Disease-Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects. J Clin Pharmacol. 2017 May;57 (5) :627-639.