Edasalonexent
Product Specifications
UNSPSC Description
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Edasalonexent.html
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
O=C(NCCNC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)C1=CC=CC=C1O
Molecular Weight
490.68
References & Citations
[1]Hammers DW, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016 Dec 22;1(21):e90341.|[2]Donovan JM, et al. A Novel NF-κB Inhibitor, Edasalonexent (CAT-1004), in Development as a Disease-Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects. J Clin Pharmacol. 2017 May;57(5):627-639.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17630/Edasalonexent-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17630/Edasalonexent-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
1204317-86-1
Available Sizes
Curated Selection
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