Edasalonexent
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
Product Specifications
CAS Number
[1204317-86-1]
Product Name Alternative
CAT-1004
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Edasalonexent.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCCNC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)C1=CC=CC=C1O
Molecular Formula
C31H42N2O3
Molecular Weight
490.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Hammers DW, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016 Dec 22;1 (21) :e90341.|[2]Donovan JM, et al. A Novel NF-κB Inhibitor, Edasalonexent (CAT-1004), in Development as a Disease-Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects. J Clin Pharmacol. 2017 May;57 (5) :627-639.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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