Pipamperone

Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) . Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7) . Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].

Product Specifications

CAS Number

[1893-33-0]

Product Name Alternative

Floropipamide; McN-JR 3345; R 3345

UNSPSC

12352005

Hazard Statement

H301, H411

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pipamperone.html

Concentration

10mM

Purity

99.89

Solubility

0.1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N

Molecular Formula

C21H30FN3O2

Molecular Weight

375.48

Precautions

H301, H411

References & Citations

[1]Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence.|[2]Oekelen DV, et al. Different regulation of rat 5-HT (2A) and rat 5-HT (2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425 (1) :21-32. |[3]Petrosino B, et al. The treatment of autism with pipamperone: a case report. European Psychiatry, 2016, 33 (S1) : S549-S549. |[4]Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6 (1) :55-7.