MC1

MC1 is a potent NLRP3 inhibitor with a KD value of 19.3 nM. MC1 shows no cytotoxicity. MC1 ameliorates cognitive deficits without eliciting adverse effects and shows an absence of hepatotoxicity. MC1 has the potential for the research of Alzheimer's disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mc1.html

Smiles

O=C(NS(C1=CC(C(C)(O)C)=CS1)(=O)=O)NC2=C(C3=CC=C([N+]([O-])=O)C=C3)C=CC4=C2CCC4

Molecular Formula

C23H23N3O6S2

Molecular Weight

501.58

References & Citations

[1]Lyu W, et al. Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease. Eur J Med Chem. 2024 Oct 21;280:116993.