MC1
Product Specifications
UNSPSC Description
MC1 is a potent NLRP3 inhibitor with a KD value of 19.3 nM. MC1 shows no cytotoxicity. MC1 ameliorates cognitive deficits without eliciting adverse effects and shows an absence of hepatotoxicity. MC1 has the potential for the research of Alzheimer's disease (AD)[1].
Target Antigen
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mc1.html
Smiles
O=C(NS(C1=CC(C(C)(O)C)=CS1)(=O)=O)NC2=C(C3=CC=C([N+]([O-])=O)C=C3)C=CC4=C2CCC4
Molecular Weight
501.58
References & Citations
[1]Lyu W, et al. Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease. Eur J Med Chem. 2024 Oct 21;280:116993.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168264/MC1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168264/
Clinical Information
Phase 3
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