Lactic acid-d4 (sodium) (60% w/w in water)

Lactic acid-d4 (DL-Lactic acid-d4) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative[3].

Product Specifications

CAS Number

[344299-52-1]

Product Name Alternative

DL-Lactic acid-d4 (sodium) ; E-270-d4 (sodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Purity

99.04

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL

Smiles

[2H]C([2H])([2H])C([2H])(O)C(O[Na])=O

Molecular Formula

C3HD4NaO3

Molecular Weight

116.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.