BNC105

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

Product Specifications

CAS Number

[945771-74-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BNC105.html

Concentration

10mM

Purity

98.27

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

COC1=CC(C(C2=C(C)OC3=C(O)C(OC)=CC=C23)=O)=CC(OC)=C1OC

Molecular Formula

C20H20O7

Molecular Weight

372.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3- (3,4,5-trimethoxybenzoyl) benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54 (17) :6014-27.|[2]Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9 (6) :1562-73.|[3]Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15 (11) :1552-60.