BNC105
BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Product Specifications
CAS Number
945771-74-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BNC105.html
Concentration
10mM
Purity
98.27
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COC1=CC(C(C2=C(C)OC3=C(O)C(OC)=CC=C23)=O)=CC(OC)=C1OC
Molecular Formula
C20H20O7
Molecular Weight
372.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3- (3,4,5-trimethoxybenzoyl) benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54 (17) :6014-27.|[2]Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9 (6) :1562-73.|[3]Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15 (11) :1552-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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