Thalidomide-O-amido-PEG-C2-NH2 (hydrochloride)

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

[2204226-02-6]

UNSPSC

12352005

Hazard Statement

H301-H312-H361

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-o-amido-peg-c2-nh2-hydrochloride.html

Purity

98.54

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl

Molecular Formula

C19H23ClN4O7

Molecular Weight

454.86

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

References & Citations

[1]Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) . J Med Chem. 2018 Feb 8;61 (3) :918-933.