GYY4137

GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity[1][2][3][4][5][6].

Product Specifications

CAS Number

[106740-09-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; COX; Interleukin Related; NF-κB; NO Synthase; STAT; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gyy4137.html

Purity

98.08

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 19.23 mg/mL (ultrasonic)

Smiles

SP(N1CCOCC1)(C2=CC=C(OC)C=C2)=S.N3CCOCC3

Molecular Formula

C15H25N2O3PS2

Molecular Weight

376.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Li L, et al. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137) : new insights into the biology of hydrogen sulfide. Circulation. 2008;117 (18) :2351-2360.|[2]Lee ZW, et al. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One. 2011;6 (6) :e21077.|[3]Li L, et al. The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med. 2013;17 (3) :365-376.|[4]Lu S, Gao Y, et al. GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. Int J Oncol. 2014;44 (4) :1259-1267.|[5]Hou X, et al. GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson's Disease. Front Pharmacol. 2017;8:741. Published 2017 Oct 30.|[6]Lu S, et al. GYY4137, a hydrogen sulfide (H2S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway[J]. International journal of oncology, 2014, 44 (4) : 1259-1267.