ESI-09
ESI-09 is a novel noncyclic nucleotide EPAC antagonist with IC50 values of 3.2 and 1.4 μM for EPAC1 and EPAC2, respectively.
Product Specifications
CAS Number
[263707-16-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ESI-09.html
Purity
99.65
Solubility
DMSO : ≥ 47 mg/mL
Smiles
O=C(C1=NOC(C(C)(C)C)=C1)/C(C#N)=N/NC2=CC(Cl)=CC=C2
Molecular Formula
C16H15ClN4O2
Molecular Weight
330.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Almahariq M, et al. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol. 2013 Jan;83 (1) :122-8.|[2]Gong B, et al. Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. Proc Natl Acad Sci U S A. 2013 Nov 26;110 (48) :19615-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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