L2H2-6OTD (diformic)
L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC50 value of 15 nM[1].
Product Specifications
UNSPSC
12352005
Target
Telomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l2h2-6otd-formic.html
Purity
99.28
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=CO.NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4.O=CO
Molecular Formula
C32H34N10O12
Molecular Weight
750.67
References & Citations
[1]Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18 (4) :4328-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP310623 20 µg
Protein Kinase A reguLatory subunit I alpha (PRKAR1A) (NM_212471) Human Recombinant Protein
Sign In for Pricing
View Details 
PDMH100412-01 20 µg
Recombinant Human Interleukin-4/IL-4 protein (His tag)
Sign In for Pricing
View Details PDMH100412-02 100 µg
Recombinant Human Interleukin-4/IL-4 protein (His tag)
Sign In for Pricing
View Details