Isoorientin
Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
Product Specifications
CAS Number
4261-42-1
Product Name Alternative
Homoorientin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Isoorientin.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=C(C2=O)C(OC(C3=CC(O)=C(O)C=C3)=C2)=CC(O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO
Molecular Formula
C21H20O11
Molecular Weight
448.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Sumalatha M, et al. Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. Nat Prod Commun. 2015 Oct;10 (10) :1703-4.|[2]Ye T, et al. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. Onco Targets Ther. 2016 Dec 12;9:7481-7492.|[3]Anilkumar K, et al. Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa. Oxid Med Cell Longev. 2017;2017:5498054.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2
Available Sizes
Frequently Asked Questions
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