Isoorientin

Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.

Product Specifications

CAS Number

[4261-42-1]

Product Name Alternative

Homoorientin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Isoorientin.html

Concentration

10mM

Purity

99.26

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=C(C2=O)C(OC(C3=CC(O)=C(O)C=C3)=C2)=CC(O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO

Molecular Formula

C21H20O11

Molecular Weight

448.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Sumalatha M, et al. Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. Nat Prod Commun. 2015 Oct;10 (10) :1703-4.|[2]Ye T, et al. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. Onco Targets Ther. 2016 Dec 12;9:7481-7492.|[3]Anilkumar K, et al. Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa. Oxid Med Cell Longev. 2017;2017:5498054.