Methyl oleanonate

Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia[1]. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects[2].

Product Specifications

CAS Number

[1721-58-0]

Product Name Alternative

3-Oxoolean-12-en-28-oic acid methyl ester

UNSPSC

12352211

Target

PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/methyl-oleanonate.html

Purity

99.81

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(OC)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

Molecular Formula

C31H48O3

Molecular Weight

468.71

References & Citations

[1]Rasmus K Petersen, et al. Pharmacophore-driven identification of PPARγ agonists from natural sources. J Comput Aided Mol Des. 2011 Feb;25 (2) :107-16.|[2]Barbara Bednarczyk-Cwynar, et al. Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines. Org Biomol Chem. 2012 Mar 21;10 (11) :2201-5