Duazomycin
Duazomycin A is a glutamine antagonist. Duazomycin A can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) in experimental allergic encephalomyelitis (EAE) without increasing toxicity[1][2].
Product Specifications
CAS Number
2508-89-6
Product Name Alternative
Duazomycin A
UNSPSC
12352211
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/duazomycin.html
Smiles
[N-]=[N+]=CC(CC[C@@H](C(O)=O)NC(C)=O)=O
Molecular Formula
C8H11N3O4
Molecular Weight
213.19
References & Citations
[1]Vogel C L, et al. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine[J]. Proceedings of the Society for Experimental Biology and Medicine, 1969, 131 (1) : 251-256.|[2]Rosenberg S, et al. Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A’[J]. Nature, 1963, 199 (4898) : 1101-1102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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