DHX9-IN-1
DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNA helicase A (DHX9) with an EC50 value of 6.94 μM in cells. DHX9-IN-1 has anti-tumor activity and can be used in the study of DHX9-related cancers[1].
Product Specifications
CAS Number
2973747-89-4
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhx9-in-1.html
Purity
98.33
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CN(C)C(C2=NC=C(N3CC(F)(F)C3)C=C2)=C1)NC4=CC=CC(NS(C)(=O)=O)=C4
Molecular Formula
C21H21F2N5O3S
Molecular Weight
461.48
References & Citations
[1]DANIELS Matthew, et al. Preparation of N-sulfonamidophenyl carboxamides as inhibitors of RNA helicase DHX9 and uses thereof. World Intellectual Property Organization, WO2023158795 A1 2023-08-24
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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