DHX9-IN-1

DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNA helicase A (DHX9) with an EC50 value of 6.94 μM in cells. DHX9-IN-1 has anti-tumor activity and can be used in the study of DHX9-related cancers[1].

Product Specifications

CAS Number

[2973747-89-4]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dhx9-in-1.html

Purity

98.33

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(C1=CN(C)C(C2=NC=C(N3CC(F)(F)C3)C=C2)=C1)NC4=CC=CC(NS(C)(=O)=O)=C4

Molecular Formula

C21H21F2N5O3S

Molecular Weight

461.48

References & Citations

[1]DANIELS Matthew, et al. Preparation of N-sulfonamidophenyl carboxamides as inhibitors of RNA helicase DHX9 and uses thereof. World Intellectual Property Organization, WO2023158795 A1 2023-08-24