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MAO-A/5-HT2AR-IN-1

MAO-A/5-HT2AR-IN-1 (compound I14) is a potent MAO-A and 5-HT2AR dual inhibitor, with IC50 values of 0.004 and 0.014 μM, respectively. MAO-A/5-HT2AR-IN-1 is a potential antidepressant agent[1].

Product Specifications

CAS Number

[2769156-00-3]

UNSPSC

12352005

Target

5-HT Receptor; Monoamine Oxidase

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-a-5-ht2ar-in-1.html

Purity

99.71

Solubility

DMF : 5 mg/mL (ultrasonic; warming; heat to 80°C) |DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C3=NC=CC4=CC(OCCCCN5CCN(CC5)C6=C(F)C=CC=C6)=CC1=C43)C=CC=C2

Molecular Formula

C30H28FN3O2

Molecular Weight

481.56

References & Citations

[1]Sun X, Li N, et al. Development of MAO-A and 5-HT2AR Dual Inhibitors with Improved Antidepressant Activity. J Med Chem. 2022 Oct 13;65 (19) :13385-13400.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAO-A; MAO-B; α-1 microglobulin

Available Sizes

Curated Selection

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