Clorsulon

Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep[1][2][3][4][5][6].

Product Specifications

CAS Number

[60200-06-8]

Product Name Alternative

L631529; MK401

UNSPSC

12352005

Hazard Statement

H319

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/clorsulon.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O

Molecular Formula

C8H8Cl3N3O4S2

Molecular Weight

380.66

Precautions

H319

References & Citations

[1]Mrozik, H., et al., 4-amino-6- (trichloroethenyl) -1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20 (9) : p. 1225-7.|[2]Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92 (3) : p. 232-41.|[3]Meaney M, et al. A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica. Parasitol Res. 2005 Jan;95 (2) :117-28. |[4]Blanco-Paniagua E, et al. Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin. Antimicrob Agents Chemother. 2023 May 17;67 (5) :e0009523.|[5]Rehbein S, et al. Plasma pharmacokinetics of clorsulon following administration of a single subcutaneous or intravenous injection to cattle. J Vet Pharmacol Ther. 2024 Mar;47 (2) :87-94. |[6]Lankas GR, et al. Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity. Food Chem Toxicol. 1992 Apr;30 (4) :297-306.