Tobramycin

Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa[2][3].

Product Specifications

CAS Number

[32986-56-4]

Product Name Alternative

Nebramycin Factor 6; Deoxykanamycin B

UNSPSC

12352005

Hazard Statement

H361

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Tobramycin.html

Purity

99.93

Solubility

DMSO : 2 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O[C@@H]([C@@H]1O[C@@]([C@@H](C[C@@H]2O)N)([H])O[C@@H]2CN)[C@H]([C@@H](C[C@@H]1N)N)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO

Molecular Formula

C18H37N5O9

Molecular Weight

467.51

Precautions

H361

References & Citations

[1]Tobramycin.|[2]VanDrisse CM, et.al. Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2021 Mar 23;118 (12) :e2022012118.|[3]Louie A, et.al. Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia. Antimicrob Agents Chemother. 2013 Jun;57 (6) :2788-92. |[4]Welles JS, et.al. Preclinical toxicology studies with tobramycin. Toxicol Appl Pharmacol. 1973 Jul;25 (3) :398-409.