Carprofen

Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

Product Specifications

CAS Number

[53716-49-7]

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy; COX; Endogenous Metabolite; FAAH

Type

Reference compound

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Carprofen.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 87.5 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)C1=CC(NC2=C3C=C(Cl)C=C2)=C3C=C1

Molecular Formula

C15H12ClNO2

Molecular Weight

273.71

Precautions

H301

References & Citations

[1]Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55 (20) :8807-26.|[2]Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov;73 (11) :1752-8.|[3]Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May;66 (5) :812-7.