Macozinone

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].

Product Specifications

CAS Number

[1377239-83-2]

Product Name Alternative

PBTZ169

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PBTZ169.html

Purity

98.46

Solubility

DMSO : 6.4 mg/mL (ultrasonic)

Smiles

O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1

Molecular Formula

C20H23F3N4O3S

Molecular Weight

456.48

Precautions

H302, H315, H319, H335

References & Citations

[1][3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Mar;6 (3) :372-83.