C004019

C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Ligand for target protein (HY-138679) ; Black: linker (HY-140189) ; Blue: E3 Ligase Ligand (HY-138678) ) [1]

Product Specifications

CAS Number

[2417159-57-8]

UNSPSC

12352005

Target

PROTACs; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling; PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/c004019.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCNC(CN(C4=NC(N5CCN(CCC5)C(C)=O)=NC(NCCC6=CC=CS6)=N4)C)=O)=O

Molecular Formula

C49H70N12O9S2

Molecular Weight

1035.29

References & Citations

[1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11 (11) :5279-5295.